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Biased agonists of the kappa opioid receptor suppress pain and itch without  causing sedation or dysphoria | Science Signaling
Biased agonists of the kappa opioid receptor suppress pain and itch without causing sedation or dysphoria | Science Signaling

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist  Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical  Neuroscience
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience

Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse |  National Institute on Drug Abuse (NIDA)
Targeting the Kappa Opioid Receptor to Reduce Drug Use and Relapse | National Institute on Drug Abuse (NIDA)

New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects
New Kappa-Opioid Receptor Agonist Curbs Pain, Avoids Side Effects

κ-opioid receptor - Wikipedia
κ-opioid receptor - Wikipedia

Kappa Receptors – Opioid Peptides
Kappa Receptors – Opioid Peptides

Mu Opiate Receptor Agonist - an overview | ScienceDirect Topics
Mu Opiate Receptor Agonist - an overview | ScienceDirect Topics

The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology  of Schizophrenia: A Review of the Evidence
The Role of Dynorphin and the Kappa Opioid Receptor in the Symptomatology of Schizophrenia: A Review of the Evidence

Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands:  Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience
Signaling Properties of Structurally Diverse Kappa Opioid Receptor Ligands: Toward in Vitro Models of in Vivo Responses | ACS Chemical Neuroscience

Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid  Agonists
Pharmaceuticals | Free Full-Text | Therapeutic Potential of Kappa Opioid Agonists

Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for  the Development of Potential Treatments of Pain with Reduced Side Effects
Molecules | Free Full-Text | Design of κ-Opioid Receptor Agonists for the Development of Potential Treatments of Pain with Reduced Side Effects

Kappa Opiate Receptor Agonist - an overview | ScienceDirect Topics
Kappa Opiate Receptor Agonist - an overview | ScienceDirect Topics

BRL 52537 hydrochloride, kappa-opioid agonist (CAS 112282-24-3) (ab120669)
BRL 52537 hydrochloride, kappa-opioid agonist (CAS 112282-24-3) (ab120669)

Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine  Dependence - ScienceDirect
Mixed Kappa/Mu Partial Opioid Agonists as Potential Treatments for Cocaine Dependence - ScienceDirect

Opioids in cancer: The κ‑opioid receptor (Review)
Opioids in cancer: The κ‑opioid receptor (Review)

Frontiers | The Kappa Opioid Receptor: From Addiction to Depression, and  Back
Frontiers | The Kappa Opioid Receptor: From Addiction to Depression, and Back

A Systematic Review on the Kappa Opioid Receptor and Its Ligands: New  Directions for the Treatment of Pain, Anxiety, Depression, and Drug Abuse |  Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage
A Systematic Review on the Kappa Opioid Receptor and Its Ligands: New Directions for the Treatment of Pain, Anxiety, Depression, and Drug Abuse | Biological and Medicinal Chemistry | ChemRxiv | Cambridge Open Engage

Structure–activity relationship investigation of triazole-based kappa  opioid receptor agonists | SpringerLink
Structure–activity relationship investigation of triazole-based kappa opioid receptor agonists | SpringerLink

Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist  Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical  Neuroscience
Discovery of Small Molecule Kappa Opioid Receptor Agonist and Antagonist Chemotypes through a HTS and Hit Refinement Strategy | ACS Chemical Neuroscience

A unique natural selective kappa-opioid receptor agonist, salvinorin A, and  its roles in human therapeutics - ScienceDirect
A unique natural selective kappa-opioid receptor agonist, salvinorin A, and its roles in human therapeutics - ScienceDirect

EX-99.2
EX-99.2

Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist,  Enhances the Diuretic Response and Limits Electrolyte Losses to  Standard-of-Care Diuretics | Hypertension
Nalfurafine, a G-Protein–Biased KOR (Kappa Opioid Receptor) Agonist, Enhances the Diuretic Response and Limits Electrolyte Losses to Standard-of-Care Diuretics | Hypertension

κ-opioid receptor - Wikipedia
κ-opioid receptor - Wikipedia

Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes  for the Kappa Opioid Receptor | Journal of Medicinal Chemistry
Structure-Based Discovery of New Antagonist and Biased Agonist Chemotypes for the Kappa Opioid Receptor | Journal of Medicinal Chemistry

Topical administration of the kappa opioid receptor agonist nalfurafine  suppresses corneal neovascularization and inflammation | Scientific Reports
Topical administration of the kappa opioid receptor agonist nalfurafine suppresses corneal neovascularization and inflammation | Scientific Reports

Frontiers | A Review of the Therapeutic Potential of Recently Developed G  Protein-Biased Kappa Agonists
Frontiers | A Review of the Therapeutic Potential of Recently Developed G Protein-Biased Kappa Agonists

Mu and delta, but not kappa, opioid agonists induce spastic paraparesis  after a short period of spinal cord ischaemia in rats† - British Journal of  Anaesthesia
Mu and delta, but not kappa, opioid agonists induce spastic paraparesis after a short period of spinal cord ischaemia in rats† - British Journal of Anaesthesia

Opioid Receptor | kappa, mu Opioid Receptor
Opioid Receptor | kappa, mu Opioid Receptor